Sixty percent of people are either heterozygous or homozygous for the MTHFR polymorphism, meaning regular folic acid is not only useless, but potentially harmful because it blocks absorption of the meagre amounts of methyl folate we receive. Methyl folate, as the activated form, completely bypasses this problem. Methyl folate is so important for methylation pathways, and a lack can contribute to depression, elevated homocysteine levels, CFS/ME, fibromyalgia, heart disease, fertility problems, and a host of other degenerative conditions. This product is so important, particularly since most supplements are full of folic acid which as I said above can cause more harm than good. Everyone should be taking this instead. Highly, highly recommended. Thanks for stocking it iHerb!!!
Posted by iHerb Customer on Jan 20, 2012 | Verified Purchase
Some people seem to need this form of folate, but for me they seem to cause problems after a week to ten days of taking them. Basically I just get a toxic flu like feeling. Too many methyl donor's seem problematic for some of us. If you need this form, they are very good, but if you don't have the mthfr polymorphism (can't convert folic acid), then these just provide too much methyl.
Posted by iHerb Customer on Aug 15, 2013 | Verified Purchase
I have taken this for over a week and I can't say I feel any difference at all. Not sure if one needs to be deficient in Folate in order to benefit. Excellent service from iHerb and competitive price.
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