I had terrible cystic acne from being on two cycles of antibiotics for two years FOR THE minor acne I had previously. Antibiotics allowed yeast to dominate my intestine and my body with their poisons (mycotoxins) which came out my skin as acne. Within two days I could tell the cysts on the back of my neck were decreasing in size and I had no new pimples on my face when I woke up. I was amazed because I had tried several other probiotics before with no availe! I highly recommend Dr. Ohhira's probiotics!