With age, the collagen and elastin content of the skin gradually decreases. As a result, the skin becomes looser, weaker, less elastic and drier. In addition, the fat pads under the skin begin to disappear; wrinkles appear and skin sags. Aging may accelerate due to sun damage, cigarette smoke or abrasive chemicals. Several good options are available for those who wish to reverse certain signs of aging, including certain medications. Natural options listed include hyaluronic acid, DMAE, HGH, antioxidants and glycolic acid.